How to Write a Resignation Letter

Published on May 18

How to Write a Resignation Letter at a Biotech Company: A Professional Guide


Learn how to write a clear, respectful resignation letter tailored to a biotech company. Includes tips, structure, and a resignation letter template for life sciences professionals.


Leaving a biotech company—whether for a new role, a career change, or personal reasons—is a significant professional transition. Given the technical nature and tight-knit environment of the life sciences industry, how you resign can impact your reputation and future opportunities.

Here’s how to write a professional resignation letter that maintains relationships and sets the tone for a smooth exit.

Why a Good Resignation Letter Matters in Biotech

Biotech companies often operate in specialized niches, and professionals tend to cross paths again across companies, clinical trials, or research institutions.

🔍 A thoughtful resignation letter:

  • Preserves your professional reputation
  • Demonstrates maturity and gratitude
  • Supports a smoother transition for your team
  • Keeps the door open for future collaborations

Key Elements of a Biotech Resignation Letter

Your resignation letter should be short, respectful, and professional. Even if your experience wasn’t perfect, focus on maintaining a positive tone.

Here are the essential components:

1. Date and Contact Information

Include the current date and your contact information, especially if you're submitting a printed or formal letter.

2. Greeting

Use a respectful greeting to your manager or HR contact.

Example: “Dear Dr. Roberts,” or “Dear [Supervisor’s Name],”

3. Statement of Resignation

Clearly state that you are resigning and provide your intended last working day.

Example: “I am writing to formally resign from my position as Clinical Sales Associate at BioGenix, effective Friday, June 14, 2025.”

4. Expression of Gratitude

Mention what you appreciated about the role or team. Be sincere but brief.

Example: “I am grateful for the opportunity to work alongside such a talented R&D team and to have contributed to groundbreaking diagnostics development.”

5. Offer to Assist in the Transition

Offering help to train a replacement or wrap up key projects is professional and appreciated.

Example: “I am committed to ensuring a smooth handover and will do everything I can to support the team during the transition.”

6. Closing and Signature

End with a polite closing and your full name.

Example: “Sincerely, [Your Name]”

Biotech Resignation Letter Template

Here’s a sample you can customize:

Subject: Resignation Letter – [Your Name]

Dear [Manager’s Name],

I am writing to formally resign from my position as [Your Title] at [Biotech Company Name], effective [Last Working Day, typically two weeks from the date].

Working at [Company Name] has been a valuable and rewarding experience. I am especially grateful for the opportunity to be part of [mention a project, team, or scientific area], and for the professional growth I’ve gained during my time here.

I am committed to ensuring a smooth transition and will assist in any way I can to transfer my responsibilities before my departure.

Thank you again for the opportunity to be part of the [Company Name] team. I hope to stay in touch and wish the company continued success.

Sincerely,  

[Your Full Name]

Additional Tips for Biotech Professionals

  • Timing matters: Biotech companies often work on long product cycles. If possible, avoid resigning during critical phases (e.g., clinical trial launches, product submissions).
  • Tell your manager first: Always have a direct conversation before submitting your formal letter.
  • Avoid technical oversharing: You don’t need to mention specific projects, IP, or competitive roles in the letter.
  • Exit interviews: Be professional, constructive, and avoid gossip—this industry is small.

Final Thoughts

In biotech, where collaboration, reputation, and innovation are tightly interwoven, how you resign is just as important as how you contribute. A polished resignation letter reinforces your professionalism and ensures you leave on a positive note.

Whether you're moving to another life sciences company, entering a new industry, or taking time off, a well-crafted resignation letter can help you close this chapter with clarity and respect.


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